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Constrained combinatorial libraries of Gp2 proteins enhance discovery of PD-L1 binders
Engineered protein ligands are used for molecular therapy, diagnostics, and industrial biotechnology. The Gp2 domain is a 45-amino acid scaffold that has been evolved for specific, high-affinity binding to multiple targets by diversification of two solvent-exposed loops. Inspired by sitewise enrichm...
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| 發表在: | ACS Comb Sci |
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| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6051759/ https://ncbi.nlm.nih.gov/pubmed/29799714 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscombsci.8b00010 |
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