Aspartate is an endogenous metabolic limitation for tumour growth

Defining the metabolic limitations of tumour growth will help develop cancer therapies(1). Cancer cells proliferate slower in tumours than in standard culture conditions, indicating that a metabolic limitation may restrict cell proliferation in vivo. Aspartate synthesis can limit cancer cell prolife...

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Publicat a:Nat Cell Biol
Autors principals: Sullivan, Lucas B., Luengo, Alba, Danai, Laura V., Bush, Lauren N., Diehl, Frances F., Hosios, Aaron M., Lau, Allison N., Elmiligy, Sarah, Malstrom, Scott, Lewis, Caroline A., Vander Heiden, Matthew G.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6051729/
https://ncbi.nlm.nih.gov/pubmed/29941931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0125-0
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