Array comparative genomic hybridization identifies high level of PI3K/Akt/mTOR pathway alterations in anal cancer recurrences

Genomic alterations of anal squamous cell carcinoma (ASCC) remain poorly understood due to the rarity of this tumor. Array comparative genomic hybridization and targeted gene sequencing were performed in 49 cases of ASCC. The most frequently altered regions (with a frequency greater than 25%) were 1...

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Vydáno v:Cancer Med
Hlavní autoři: Cacheux, Wulfran, Tsantoulis, Petros, Briaux, Adrien, Vacher, Sophie, Mariani, Pascale, Richard‐Molard, Marion, Buecher, Bruno, Richon, Sophie, Jeannot, Emmanuelle, Lazartigues, Julien, Rouleau, Etienne, Mariani, Odette, El Alam, Elsy, Cros, Jérôme, Roman‐Roman, Sergio, Mitry, Emmanuel, Girard, Elodie, Dangles‐Marie, Virginie, Lièvre, Astrid, Bièche, Ivan
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Cancer Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6051172/
https://ncbi.nlm.nih.gov/pubmed/29804324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.1533
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