Mutational analysis of anal cancers demonstrates frequent PIK3CA mutations associated with poor outcome after salvage abdominoperineal resection

BACKGROUND: A better understanding of the molecular profile of anal squamous cell carcinomas (ASCCs) is necessary to consider new therapeutic approaches, and the identification of prognostic and predictive factors for response to treatment. METHODS: We retrospectively analysed tumours from ASCC pati...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Principais autores: Cacheux, Wulfran, Rouleau, Etienne, Briaux, Adrien, Tsantoulis, Petros, Mariani, Pascale, Richard-Molard, Marion, Buecher, Bruno, Dangles-Marie, Virginie, Richon, Sophie, Lazartigues, Julien, Jeannot, Emmanuelle, Farkhondeh, Fereshteh, Sastre-Garau, Xavier, de La Rochefordière, Anne, Labib, Alain, Falcou, Marie-Christine, Stevens, Denise, Roth, Arnaud, Roman-Roman, Sergio, Mitry, Emmanuel, Bièche, Ivan, Lièvre, Astrid
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984471/
https://ncbi.nlm.nih.gov/pubmed/27219019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.144
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