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High-fidelity discrete modeling of the HPA axis: a study of regulatory plasticity in biology

BACKGROUND: The hypothalamic-pituitary-adrenal (HPA) axis is a central regulator of stress response and its dysfunction has been associated with a broad range of complex illnesses including Gulf War Illness (GWI) and Chronic Fatigue Syndrome (CFS). Though classical mathematical approaches have been...

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Bibliografische gegevens
Gepubliceerd in:BMC Syst Biol
Hoofdauteurs: Sedghamiz, Hooman, Morris, Matthew, Craddock, Travis J. A., Whitley, Darrell, Broderick, Gordon
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050677/
https://ncbi.nlm.nih.gov/pubmed/30016990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12918-018-0599-1
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