A carregar...
Direct heterobenzylic fluorination, difluorination and trifluoromethylthiolation with dibenzenesulfonamide derivatives
Functionalization of heterocyclic scaffolds with mono- or difluoroalkyl groups provides unique opportunities to modulate drug pK(a), influence potency and membrane permeability, and attenuate metabolism. While advances in the addition of fluoroalkyl radicals to heterocycles have been made, direct C(...
Na minha lista:
| Publicado no: | Chem Sci |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2018
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6050628/ https://ncbi.nlm.nih.gov/pubmed/30061993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc01221k |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|