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Aryl bis-sulfonamides bind to the active site of a homotrimeric isoprenoid biosynthesis enzyme IspF and extract the essential divalent metal cation cofactor
Characterizing the mode of action of non-covalent inhibitors in multisubunit enzymes often presents a great challenge. Most of the conventionally used methods are based on ensemble measurements of protein–ligand binding in bulk solution. They often fail to accurately describe multiple binding proces...
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| Publicado en: | Chem Sci |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Royal Society of Chemistry
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6050538/ https://ncbi.nlm.nih.gov/pubmed/30079212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc00814k |
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