Direct observation of DNA target searching and cleavage by CRISPR-Cas12a

Cas12a (also called Cpf1) is a representative type V-A CRISPR effector RNA-guided DNA endonuclease, which provides an alternative to type II CRISPR–Cas9 for genome editing. Previous studies have revealed that Cas12a has unique features distinct from Cas9, but the detailed mechanisms of target search...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Jeon, Yongmoon, Choi, You Hee, Jang, Yunsu, Yu, Jihyeon, Goo, Jiyoung, Lee, Gyejun, Jeong, You Kyeong, Lee, Seung Hwan, Kim, In-San, Kim, Jin-Soo, Jeong, Cherlhyun, Lee, Sanghwa, Bae, Sangsu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050341/
https://ncbi.nlm.nih.gov/pubmed/30018371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05245-x
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