Direct observation of DNA target searching and cleavage by CRISPR-Cas12a

Cas12a (also called Cpf1) is a representative type V-A CRISPR effector RNA-guided DNA endonuclease, which provides an alternative to type II CRISPR–Cas9 for genome editing. Previous studies have revealed that Cas12a has unique features distinct from Cas9, but the detailed mechanisms of target search...

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Publicado no:Nat Commun
Main Authors: Jeon, Yongmoon, Choi, You Hee, Jang, Yunsu, Yu, Jihyeon, Goo, Jiyoung, Lee, Gyejun, Jeong, You Kyeong, Lee, Seung Hwan, Kim, In-San, Kim, Jin-Soo, Jeong, Cherlhyun, Lee, Sanghwa, Bae, Sangsu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050341/
https://ncbi.nlm.nih.gov/pubmed/30018371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05245-x
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