Impaired DNA demethylation of C/EBP sites causes premature aging

Changes in DNA methylation are among the best-documented epigenetic alterations accompanying organismal aging. However, whether and how altered DNA methylation is causally involved in aging have remained elusive. GADD45α (growth arrest and DNA damage protein 45A) and ING1 (inhibitor of growth family...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Schäfer, Andrea, Mekker, Bernadette, Mallick, Medhavi, Vastolo, Viviana, Karaulanov, Emil, Sebastian, Dominik, von der Lippen, Carina, Epe, Bernd, Downes, Damien J., Scholz, Carola, Niehrs, Christof
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6049513/
https://ncbi.nlm.nih.gov/pubmed/29884649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.311969.118
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