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The Dfm1 derlin is required for ERAD retrotranslocation of integral membrane proteins
ER associated degradation (ERAD) removes misfolded proteins from the ER membrane and lumen by the ubiquitin-proteasome pathway. Retrotranslocation of ubiquitinated substrates to the cytosol is a universal feature of ERAD that requires the Cdc48 AAA-ATPase. Despite intense efforts, the mechanism of E...
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| Publié dans: | Mol Cell |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6049073/ https://ncbi.nlm.nih.gov/pubmed/29351849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.12.012 |
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