Loading...

HRD Complex Self-Remodeling Enables a Novel Route of Membrane Protein Retrotranslocation

ER-associated degradation (ERAD) targets misfolded ER proteins for degradation. Retrotranslocation, a key feature of ERAD, entails removal of ubiquitinated substrates into the cytosol for proteasomal destruction. Recently, it has been shown that the Hrd1 E3 ligase forms a retrotranslocation channel...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:iScience
Main Authors: Neal, Sonya, Syau, Della, Nejatfard, Anahita, Nadeau, Samantha, Hampton, Randolph Y.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7481253/
https://ncbi.nlm.nih.gov/pubmed/32891886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101493
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!