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HRD Complex Self-Remodeling Enables a Novel Route of Membrane Protein Retrotranslocation
ER-associated degradation (ERAD) targets misfolded ER proteins for degradation. Retrotranslocation, a key feature of ERAD, entails removal of ubiquitinated substrates into the cytosol for proteasomal destruction. Recently, it has been shown that the Hrd1 E3 ligase forms a retrotranslocation channel...
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| Publicado no: | iScience |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7481253/ https://ncbi.nlm.nih.gov/pubmed/32891886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101493 |
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