The Caenorhabditis elegans Ortholog of TDP-43 Regulates the Chromatin Localization of the Heterochromatin Protein 1 Homolog HPL-2

TDP-1 is the Caenorhabditis elegans ortholog of mammalian TDP-43, which is strongly implicated in the etiology of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We discovered that deletion of the tdp-1 gene results in enhanced nuclear RNA interference (RNAi). As nuclear RNAi...

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Gepubliceerd in:Mol Cell Biol
Hoofdauteurs: Saldi, Tassa K., Gonzales, Patrick, Garrido-Lecca, Alfonso, Dostal, Vishantie, Roberts, Christine M., Petrucelli, Leonard, Link, Christopher D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048318/
https://ncbi.nlm.nih.gov/pubmed/29760282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00668-17
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