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TDP-1/TDP-43 Regulates Stress Signaling and Age-Dependent Proteotoxicity in Caenorhabditis elegans

TDP-43 is a multifunctional nucleic acid binding protein linked to several neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia. To learn more about the normal biological and abnormal pathological role of this protein, we turned to Caenorhabditis elega...

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Hlavní autoři: Vaccaro, Alexandra, Tauffenberger, Arnaud, Ash, Peter E. A., Carlomagno, Yari, Petrucelli, Leonard, Parker, J. Alex
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390363/
https://ncbi.nlm.nih.gov/pubmed/22792076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002806
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