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TDP-43 Toxicity Proceeds via Calcium Dysregulation and Necrosis in Aging Caenorhabditis elegans Motor Neurons
Amyotrophic lateral sclerosis (ALS) is a heterogeneous disease with either sporadic or genetic origins characterized by the progressive degeneration of motor neurons. At the cellular level, ALS neurons show protein misfolding and aggregation phenotypes. Transactive response DNA-binding protein 43 (T...
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| Publié dans: | J Neurosci |
|---|---|
| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Society for Neuroscience
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4262699/ https://ncbi.nlm.nih.gov/pubmed/25186754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2495-13.2014 |
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