Act1 is a negative regulator in T and B cells via direct inhibition of STAT3

Although Act1 (adaptor for IL-17 receptors) is necessary for IL-17-mediated inflammatory responses, Act1- (but not Il17ra-, Il17rc-, or Il17rb-) deficient mice develop spontaneous SLE- and Sjögren’s-like diseases. Here, we show that Act1 functions as a negative regulator in T and B cells via direct...

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Publicado no:Nat Commun
Main Authors: Zhang, Cun-Jin, Wang, Chenhui, Jiang, Meiling, Gu, Chunfang, Xiao, Jianxin, Chen, Xing, Martin, Bradley N., Tang, Fangqiang, Yamamoto, Erin, Xian, Yibo, Wang, Han, Li, Fengling, Sartor, R. Balfour, Smith, Howard, Husni, M. Elaine, Shi, Fu-Dong, Gao, Ji, Carman, Julie, Dongre, Ashok, McKarns, Susan C., Coppieters, Ken, Jørgensen, Trine N., Leonard, Warren J., Li, Xiaoxia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048100/
https://ncbi.nlm.nih.gov/pubmed/30013031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04974-3
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