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Lack of T cells in Act1-deficient mice results in elevated IgM-specific autoantibodies but reduced lupus-like disease

SUMMARY: Act1 is a negative regulator of BAFF and CD40L-induced signaling. Balb/c mice lacking Act1 develop systemic autoimmunity resembling Systemic Lupus Erythematosus (SLE) and Sjögren's Syndrome (SjS). SLE and SjS are characterized by anti-nuclear IgG autoantibody (ANA-IgG) production and i...

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Detalhes bibliográficos
Main Authors: Johnson, Angela C., Davison, Laura M., Giltiay, Natalia V., Vareechon, Chairut, Li, Xiaoxia, Jørgensen, Trine N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712797/
https://ncbi.nlm.nih.gov/pubmed/22585710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201142238
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