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Lack of T cells in Act1-deficient mice results in elevated IgM-specific autoantibodies but reduced lupus-like disease
SUMMARY: Act1 is a negative regulator of BAFF and CD40L-induced signaling. Balb/c mice lacking Act1 develop systemic autoimmunity resembling Systemic Lupus Erythematosus (SLE) and Sjögren's Syndrome (SjS). SLE and SjS are characterized by anti-nuclear IgG autoantibody (ANA-IgG) production and i...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3712797/ https://ncbi.nlm.nih.gov/pubmed/22585710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201142238 |
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