Spontaneous loss of tolerance of autoreative B cell in Act1-deficient AM14 Tg rheumatoid factor (RF) mice

Self-reactive B cells in BALB/c AM14 transgenic (AM14 Tg) rheumatoid factor (RF) mice are not subject to central or peripheral toleralization. Instead, they remain at a stage of “clonal ignorance”, i.e. they do not proliferate and differentiate into Ab-producing cells. However, the immunoregulatory...

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Main Authors: Giltiay, Natalia V., Lu, Yi, Cullen, Jaime L., Jørgensen, Trine N., Shlomchik, Mark J., Li, Xiaoxia
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893933/
https://ncbi.nlm.nih.gov/pubmed/23904159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300152
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