IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression

NOTCH1 signalling contributes to defective remyelination by impairing differentiation of oligodendrocyte progenitor cells (OPCs). Here we report that IL-17 stimulation induces NOTCH1 activation in OPCs, contributing to Th17-mediated demyelinating disease. Mechanistically, IL-17R interacts with NOTCH...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Wang, Chenhui, Zhang, Cun-Jin, Martin, Bradley N., Bulek, Katarzyna, Kang, Zizhen, Zhao, Junjie, Bian, Guanglin, Carman, Julie A., Gao, Ji, Dongre, Ashok, Xue, Haibo, Miller, Stephen D., Qian, Youcun, Hambardzumyan, Dolores, Hamilton, Tom, Ransohoff, Richard M., Li, Xiaoxia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460031/
https://ncbi.nlm.nih.gov/pubmed/28561022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15508
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados