Psoriasis-associated variant Act1 D10N with impaired regulation by Hsp90

Act1 is an essential adaptor molecule in IL-17-mediated signaling and is recruited to the IL-17 receptor upon IL-17 stimulation. Here, we report that Act1 is a client protein of the molecular chaperone, Hsp90. The Act1 variant (D10N) linked to psoriasis susceptibility is defective in its interaction...

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Detalhes bibliográficos
Main Authors: Wang, Chenhui, Wu, Ling, Bulek, Katarzyna, Martin, Bradley N., Zepp, Jarod A., Kang, Zizhen, Liu, Caini, Herjan, Tomasz, Misra, Saurav, Carman, Julie A., Gao, Ji, Dongre, Ashok, Han, Shujie, Bunting, Kevin D., Ko, Jennifer S., Xiao, Hui, Kuchroo, Vijay K., Ouyang, Wenjun, Li, Xiaoxia
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522792/
https://ncbi.nlm.nih.gov/pubmed/23202271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2479
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