IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression

NOTCH1 signalling contributes to defective remyelination by impairing differentiation of oligodendrocyte progenitor cells (OPCs). Here we report that IL-17 stimulation induces NOTCH1 activation in OPCs, contributing to Th17-mediated demyelinating disease. Mechanistically, IL-17R interacts with NOTCH...

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Publicado en:Nat Commun
Autores principales: Wang, Chenhui, Zhang, Cun-Jin, Martin, Bradley N., Bulek, Katarzyna, Kang, Zizhen, Zhao, Junjie, Bian, Guanglin, Carman, Julie A., Gao, Ji, Dongre, Ashok, Xue, Haibo, Miller, Stephen D., Qian, Youcun, Hambardzumyan, Dolores, Hamilton, Tom, Ransohoff, Richard M., Li, Xiaoxia
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460031/
https://ncbi.nlm.nih.gov/pubmed/28561022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15508
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