H1N1pdm09 Influenza Virus and Its Descendants Lack Extra-epitopic Amino Acid Residues Associated With Reduced Recognition by M1(58-66)-Specific CD8(+) T Cells

Extra-epitopic amino acid residues affect recognition of human influenza A viruses (IAVs) by CD8(+) T-lymphocytes (CTLs) specific for the highly conserved HLA-A*0201 restricted M1(58-66) epitope located in the matrix 1 (M1) protein. These residues are absent in the M1 protein of the 2009-pandemic IA...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: van de Sandt, Carolien E, Sagong, Kyung A, Pronk, Mark R, Bestebroer, Theo M, Spronken, Monique I, Koopmans, Marion P G, Fouchier, Ron A M, Rimmelzwaan, Guus F
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047425/
https://ncbi.nlm.nih.gov/pubmed/29659927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy218
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