Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1

[Image: see text] Bone Morphogenetic Protein 1 (BMP1) inhibition is a potential method for treating fibrosis because BMP1, a member of the zinc metalloprotease family, is required to convert pro-collagen to collagen. A novel class of reverse hydroxamate BMP1 inhibitors was discovered, and cocrystal...

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Bibliografski detalji
Izdano u:ACS Med Chem Lett
Glavni autori: Kallander, Lara S., Washburn, David, Hilfiker, Mark A., Eidam, Hilary Schenck, Lawhorn, Brian G., Prendergast, Joanne, Fox, Ryan, Dowdell, Sarah, Manns, Sharada, Hoang, Tram, Zhao, Steve, Ye, Guosen, Hammond, Marlys, Holt, Dennis A., Roethke, Theresa, Hong, Xuan, Reid, Robert A., Gampe, Robert, Zhang, Hong, Diaz, Elsie, Rendina, Alan R., Quinn, Amy M., Willette, Bob
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2018
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047045/
https://ncbi.nlm.nih.gov/pubmed/30034610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00173
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