Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4)

[Image: see text] GSK2798745, a clinical candidate, was identified as an inhibitor of the transient receptor potential vanilloid 4 (TRPV4) ion channel for the treatment of pulmonary edema associated with congestive heart failure. We discuss the lead optimization of this novel spirocarbamate series a...

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Publicat a:ACS Med Chem Lett
Autors principals: Brooks, Carl A., Barton, Linda S., Behm, David J., Eidam, Hilary S., Fox, Ryan M., Hammond, Marlys, Hoang, Tram H., Holt, Dennis A., Hilfiker, Mark A., Lawhorn, Brian G., Patterson, Jaclyn R., Stoy, Patrick, Roethke, Theresa J., Ye, Guosen, Zhao, Steve, Thorneloe, Kevin S., Goodman, Krista B., Cheung, Mui
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2019
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691566/
https://ncbi.nlm.nih.gov/pubmed/31413810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00274
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