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Synthesis and Evaluation of a (18)F-Labeled Triazinediamine Analogue for Imaging Mutant IDH1 Expression in Gliomas by PET

[Image: see text] Mutations in the isocitrate dehydrogenase gene 1 (IDH1) are common in gliomas. Studies suggest that IDH1 mutations are early events in glioma formation and are important drivers of malignant progression. Herein, we report the synthesis and evaluation of a (18)F-labeled triazinediam...

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Publié dans:ACS Med Chem Lett
Auteurs principaux: Chitneni, Satish K., Yan, Hai, Zalutsky, Michael R.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2018
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047021/
https://ncbi.nlm.nih.gov/pubmed/30034587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00478
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