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Feasibility of Developing Radiotracers for MDM2: Synthesis and Preliminary Evaluation of an (18)F-Labeled Analogue of the MDM2 Inhibitor SP-141
Murine double minute 2 (MDM2), a negative regulator of the p53 tumor suppressor protein, is overexpressed in several human cancers. Herein we investigate the feasibility of developing (18)F-labeled compounds based on the small molecule inhibitor SP-141 for imaging tumor MDM2 expression levels with p...
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| Publicado no: | Pharmaceuticals (Basel) |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8070256/ https://ncbi.nlm.nih.gov/pubmed/33924734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14040358 |
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