LonP1 Differently Modulates Mitochondrial Function and Bioenergetics of Primary Versus Metastatic Colon Cancer Cells

Mitochondrial Lon protease (LonP1) is a multi-function enzyme that regulates mitochondrial functions in several human malignancies, including colorectal cancer (CRC). The mechanism(s) by which LonP1 contributes to colorectal carcinogenesis is not fully understood. We found that silencing LonP1 leads...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Gibellini, Lara, Losi, Lorena, De Biasi, Sara, Nasi, Milena, Lo Tartaro, Domenico, Pecorini, Simone, Patergnani, Simone, Pinton, Paolo, De Gaetano, Anna, Carnevale, Gianluca, Pisciotta, Alessandra, Mariani, Francesco, Roncucci, Luca, Iannone, Anna, Cossarizza, Andrea, Pinti, Marcello
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6046640/
https://ncbi.nlm.nih.gov/pubmed/30038898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00254
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