Inhibition of Lon protease by triterpenoids alters mitochondria and is associated to cell death in human cancer cells

Mitochondrial Lon protease (Lon) regulates several mitochondrial functions, and is inhibited by the anticancer molecule triterpenoid 2-cyano-3, 12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO), or by its C-28 methyl ester derivative (CDDO-Me). To analyze the mechanism of action of triterpenoids, we in...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Gibellini, Lara, Pinti, Marcello, Bartolomeo, Regina, De Biasi, Sara, Cormio, Antonella, Musicco, Clara, Carnevale, Gianluca, Pecorini, Simone, Nasi, Milena, De Pol, Anto, Cossarizza, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694845/
https://ncbi.nlm.nih.gov/pubmed/26314956
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