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MiR‐21 role in aspirin‐dependent PPARα and multidrug resistance protein 4 upregulation
BACKGROUND: A mechanism involved in high on‐aspirin treatment residual platelet reactivity is platelet multidrug resistance protein 4 (MRP4) overexpression. Aspirin enhances platelet MRP4 expression with a PPARα‐dependent mechanism and reduces miR‐21 expression that, in turn, downregulates PPARα exp...
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| Publicado no: | Res Pract Thromb Haemost |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6046603/ https://ncbi.nlm.nih.gov/pubmed/30046765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/rth2.12104 |
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