MiR‐21 role in aspirin‐dependent PPARα and multidrug resistance protein 4 upregulation

BACKGROUND: A mechanism involved in high on‐aspirin treatment residual platelet reactivity is platelet multidrug resistance protein 4 (MRP4) overexpression. Aspirin enhances platelet MRP4 expression with a PPARα‐dependent mechanism and reduces miR‐21 expression that, in turn, downregulates PPARα exp...

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Bibliografiska uppgifter
I publikationen:Res Pract Thromb Haemost
Huvudupphovsmän: Massimi, Isabella, Alemanno, Laura, Guarino, Maria L., Guerriero, Raffaella, Frati, Luigi, Biasucci, Luigi, Pulcinelli, Fabio M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2018
Ämnen:
Online‐only Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6046603/
https://ncbi.nlm.nih.gov/pubmed/30046765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/rth2.12104
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