From Human Megakaryocytes to Platelets: Effects of Aspirin on High-Mobility Group Box 1/Receptor for Advanced Glycation End Products Axis

Platelets (PLTs) are the major source of high-mobility group box 1 (HMGB1), a protein that is involved in sterile inflammation of blood vessels and thrombosis. Megakaryocytes (MKs) synthesize HMGB1 and transfer both protein and mRNA into PLTs and PLT-derived microvesicles (MV). Free HMGB1 found in s...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Mardente, Stefania, Mari, Emanuela, Massimi, Isabella, Tafani, Marco, Guerriero, Raffaella, Morsilli, Ornella, Pulcinelli, Fabio M., Bianchi, Marco E., Zicari, Alessandra
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770369/
https://ncbi.nlm.nih.gov/pubmed/29375570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01946
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