Aspirin influences megakaryocytic gene expression leading to up-regulation of multidrug resistance protein-4 in human platelets

AIM: The aim of the study was to investigate whether human megakaryocytic cells have an adaptive response to aspirin treatment, leading to an enhancement of multidrug resistance protein-4 (MRP4) expression in circulating platelets responsible for a reduced aspirin action. We recently found that plat...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Massimi, Isabella, Guerriero, Raffaella, Lotti, Lavinia Vittoria, Lulli, Valentina, Borgognone, Alessandra, Romani, Federico, Barillà, Francesco, Gaudio, Carlo, Gabbianelli, Marco, Frati, Luigi, Pulcinelli, Fabio M
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256623/
https://ncbi.nlm.nih.gov/pubmed/24902864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12432
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