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Inactivation of hepatic ATRX in Atrx Foxg1cre mice prevents reversal of aging-like phenotypes by thyroxine

ATRX is an ATP-dependent chromatin remodeler required for the maintenance of genomic integrity. We previously reported that conditional Atrx ablation in the mouse embryonic forebrain and anterior pituitary using the Foxg1cre driver causes reduced health and lifespan. In these mice, premature aging-l...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Rowland, Megan E., Jiang, Yan, Beier, Frank, Bérubé, Nathalie G.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6046231/
https://ncbi.nlm.nih.gov/pubmed/29883366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101462
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