A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity

KEY POINTS: Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells are required to eliminate cancer cells. We analysed the Ca(2+) dependence of CTL and NK cell cytotoxicity and found that in particular CTLs have a very low optimum of [Ca(2+)](i) (between 122 and 334 nm) and [Ca(2+)](o) (betwee...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Zhou, Xiao, Friedmann, Kim S., Lyrmann, Hélène, Zhou, Yan, Schoppmeyer, Rouven, Knörck, Arne, Mang, Sebastian, Hoxha, Cora, Angenendt, Adrian, Backes, Christian S., Mangerich, Carmen, Zhao, Renping, Cappello, Sabrina, Schwär, Gertrud, Hässig, Carmen, Neef, Marc, Bufe, Bernd, Zufall, Frank, Kruse, Karsten, Niemeyer, Barbara A., Lis, Annette, Qu, Bin, Kummerow, Carsten, Schwarz, Eva C., Hoth, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Special section: Intracellular calcium signalling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6046087/
https://ncbi.nlm.nih.gov/pubmed/29368348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP274964
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