Effects of the 1-N-(4-Amino-2S-hydroxybutyryl) and 6′-N-(2-Hydroxyethyl) Substituents on Ribosomal Selectivity, Cochleotoxicity and Antibacterial Activity in the Sisomicin Class of Aminoglycoside Antibiotics

Syntheses of the 6′-N-(2-hydroxyethyl) and 1-N-(4-amino-2S-hydroxybutyryl) derivatives of the 4,6-aminoglycoside sisomicin and that of the doubly modified 1-N-(4-amino-2S-hydroxybutyryl)-6′-N-(2-hydroxyethyl) derivative known as plazomicin are reported together with their antibacterial and antiribos...

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Detalles Bibliográficos
Publicado en:ACS Infect Dis
Main Authors: Sonousi, Amr, Sarpe, Vikram A., Brilkova, Margarita, Schacht, Jochen, Vasella, Andrea, Böttger, Erik C., Crich, David
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6045441/
https://ncbi.nlm.nih.gov/pubmed/29708331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.8b00052
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