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Mutational Analysis of a Conserved Glutamate Reveals Unique Mechanistic and Structural Features of the Phosphatase PRL-3

[Image: see text] Phosphatase of regenerating liver (PRL)-3 (PTP4A3) has gained much attention in cancer research due to its involvement in tumor promoting and metastatic processes. It belongs to the protein tyrosine phosphatase (PTP) superfamily and is thought to follow the catalytic mechanism shar...

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Detalhes bibliográficos
Publicado no:ACS Omega
Main Authors: Hoeger, Birgit, Rios, Pablo, Berteotti, Anna, Hoermann, Bernhard, Duan, Guangyou, Köhn, Maja
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044973/
https://ncbi.nlm.nih.gov/pubmed/30023603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.7b01208
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