Small-Molecule Inhibitors of the NusB–NusE Protein–Protein Interaction with Antibiotic Activity

[Image: see text] The NusB–NusE protein–protein interaction (PPI) is critical to the formation of stable antitermination complexes required for stable RNA transcription in all bacteria. This PPI is an emerging antibacterial drug target. Pharmacophore-based screening of the mini-Maybridge compound li...

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Publicado en:ACS Omega
Autores principales: Cossar, Peter J., Abdel-Hamid, Mohammed K., Ma, Cong, Sakoff, Jennette A., Trinh, Trieu N., Gordon, Christopher P., Lewis, Peter J., McCluskey, Adam
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2017
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044933/
https://ncbi.nlm.nih.gov/pubmed/30023707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.7b00273
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