Small-Molecule Inhibitors of the NusB–NusE Protein–Protein Interaction with Antibiotic Activity

[Image: see text] The NusB–NusE protein–protein interaction (PPI) is critical to the formation of stable antitermination complexes required for stable RNA transcription in all bacteria. This PPI is an emerging antibacterial drug target. Pharmacophore-based screening of the mini-Maybridge compound li...

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Udgivet i:ACS Omega
Main Authors: Cossar, Peter J., Abdel-Hamid, Mohammed K., Ma, Cong, Sakoff, Jennette A., Trinh, Trieu N., Gordon, Christopher P., Lewis, Peter J., McCluskey, Adam
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2017
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044933/
https://ncbi.nlm.nih.gov/pubmed/30023707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.7b00273
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