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In Vitro Protein Stability of Two Naturally Occurring Thiopurine S-Methyltransferase Variants: Biophysical Characterization of TPMT*6 and TPMT*8
[Image: see text] Thiopurine S-methyltransferase (TPMT) is a polymorphic enzyme involved in the metabolism and inactivation of thiopurine substances administered as immunosuppressants in the treatment of malignancies and autoimmune diseases. In this study, the naturally occurring variants, TPMT*6 (Y...
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| Publicado en: | ACS Omega |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Chemical Society
2017
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6044926/ https://ncbi.nlm.nih.gov/pubmed/30023734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.7b00801 |
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