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Heterodimerization of Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Leads to Increased M(2)R Affinity and Selectivity

[Image: see text] In search for selective ligands for the muscarinic acetylcholine receptor (MR) subtype M(2), the dimeric ligand approach, that is combining two pharmacophores in one and the same molecule, was pursued. Different types (agonists, antagonists, orthosteric, and allosteric) of monomeri...

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Detalhes bibliográficos
Publicado no:ACS Omega
Main Authors: She, Xueke, Pegoli, Andrea, Mayr, Judith, Hübner, Harald, Bernhardt, Günther, Gmeiner, Peter, Keller, Max
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044897/
https://ncbi.nlm.nih.gov/pubmed/30023530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.7b01085
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