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Study of Molecular Mechanisms of α-Synuclein Assembly: Insight into a Cross-β Structure in the N-Termini of New α-Synuclein Fibrils

[Image: see text] Parkinson’s disease is characterized by the self-assembly of α-synuclein (AS), in which its aggregates accumulate in the substantia nigra. The molecular mechanisms of the self-assembly of AS are challenging because AS is a relatively large intrinsically disordered protein, consisti...

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Bibliografske podrobnosti
izdano v:ACS Omega
Main Authors: Bloch, Daniel Nir, Miller, Yifat
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2017
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044890/
https://ncbi.nlm.nih.gov/pubmed/30023693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.7b00459
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