Role of Pseudoisocytidine Tautomerization in Triplex-Forming Oligonucleotides: In Silico and in Vitro Studies

[Image: see text] Pseudoisocytidine ((Ψ)C) is a synthetic cytidine analogue that can target DNA duplex to form parallel triplex at neutral pH. Pseudoisocytidine has mainly two tautomers, of which only one is favorable for triplex formation. In this study, we investigated the effect of sequence on (Ψ...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:ACS Omega
Autores principales: Hartono, Yossa Dwi, Pabon-Martinez, Y. Vladimir, Uyar, Arzu, Wengel, Jesper, Lundin, Karin E., Zain, Rula, Smith, C. I. Edvard, Nilsson, Lennart, Villa, Alessandra
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2017
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044803/
https://ncbi.nlm.nih.gov/pubmed/30023656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.7b00347
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares