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Gram-Scale Synthesis of a β-Secretase 1 (BACE 1) Inhibitor
[Image: see text] Development of a scalable synthesis of an oxazine class of β-secretase inhibitor is described. Trifluoromethylated acyloin synthesis by the reaction of a mandelic acid with trifluoroacetic anhydride in the presence of pyridine (Dakin–West reaction) was used as an efficient strategy...
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| Publicado no: | ACS Omega |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2017
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6044763/ https://ncbi.nlm.nih.gov/pubmed/30023606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.6b00362 |
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