A Post-Transcriptional Feedback Mechanism for Noise Suppression and Fate Stabilization

Diverse biological systems utilize fluctuations (‘noise’) in gene-expression to drive lineage-commitment decisions. However, once a commitment is made, noise becomes detrimental to reliable function, and the mechanisms enabling post-commitment noise suppression are unclear. Here, we find that archit...

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發表在:Cell
Main Authors: Hansen, Maike M. K., Wen, Winnie Y., Ingerman, Elena, Razooky, Brandon S., Thompson, Cassandra E., Dar, Roy D., Chin, Charles, Simpson, Michael L., Weinberger, Leor S.
格式: Artigo
語言:Inglês
出版: 2018
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044448/
https://ncbi.nlm.nih.gov/pubmed/29754821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.04.005
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