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Towards monitoring conformational changes of the GPCR neurotensin receptor 1 by single-molecule FRET
Neurotensin receptor 1 (NTSR1) is a G protein-coupled receptor that is important for signaling in the brain and the gut. Its agonist ligand neurotensin (NTS), a 13-amino-acid peptide, binds with nanomolar affinity from the extracellular side to NTSR1 and induces conformational changes that trigger i...
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| Publicado no: | Proc SPIE Int Soc Opt Eng |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6044442/ https://ncbi.nlm.nih.gov/pubmed/30013286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1117/12.2286787 |
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