Lineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm

Molecular regulation of cell fate decisions underlies health and disease. To identify molecules that are active or regulated during a decision, and not before or after, the decision time point is crucial. However, cell fate markers are usually delayed and the time of decision therefore unknown. Fort...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Strasser, Michael K., Hoppe, Philipp S., Loeffler, Dirk, Kokkaliaris, Konstantinos D., Schroeder, Timm, Theis, Fabian J., Marr, Carsten
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6043612/
https://ncbi.nlm.nih.gov/pubmed/30002371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05037-3
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