Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor

Lipoteichoic acid (LTA) and lipopolysaccharide (LPS) are bacterial lipids that stimulate pro-inflammatory cytokine production, thereby exacerbating sepsis pathophysiology. Proprotein convertase subtilisin/kexin type 9 (PCSK9) negatively regulates uptake of cholesterol by downregulating hepatic lipop...

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Pubblicato in:Sci Rep
Autori principali: Grin, Peter M., Dwivedi, Dhruva J., Chathely, Kevin M., Trigatti, Bernardo L., Prat, Annik, Seidah, Nabil G., Liaw, Patricia C., Fox-Robichaud, Alison E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6043579/
https://ncbi.nlm.nih.gov/pubmed/30002483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28777-0
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