MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway

Major histocompatibility complex class II (MHC II) expression and turn-over are regulated via its ubiquitination by the membrane associated RING-CH 1 (MARCH1) E3 ligase. Unexpectedly, we show that MHC II ubiquitination also impacts MHC I. Lack of MARCH1 in B cells and dendritic cells (DCs) resulted...

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Udgivet i:PLoS One
Main Authors: Wilson, Kayla R., Liu, Haiyin, Healey, Geraldine, Vuong, Vivian, Ishido, Satoshi, Herold, Marco J., Villadangos, Jose A., Mintern, Justine D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6042767/
https://ncbi.nlm.nih.gov/pubmed/30001419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200540
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