Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor

The inflammasomes are signaling platforms that promote the activation of inflammatory caspases such as caspases-1, -4, -5, and -11. Recent studies identified gasdermin D (GSDMD) as an effector for pyroptosis downstream of the inflammasome signaling pathways. Cleavage of GSDMD by inflammatory caspase...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Yang, Jie, Liu, Zhonghua, Wang, Chuanping, Yang, Rui, Rathkey, Joseph K., Pinkard, Otis W., Shi, Wuxian, Chen, Yinghua, Dubyak, George R., Abbott, Derek W., Xiao, Tsan Sam
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6042100/
https://ncbi.nlm.nih.gov/pubmed/29891674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1800562115
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