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An archaeal primase functions as a nanoscale caliper to define primer length

The cellular replicative DNA polymerases cannot initiate DNA synthesis without a priming 3′ OH. During DNA replication, this is supplied in the context of a short RNA primer molecule synthesized by DNA primase. The primase of archaea and eukaryotes, despite having varying subunit compositions, share...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Yan, Jiangyu, Holzer, Sandro, Pellegrini, Luca, Bell, Stephen D.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6042085/
https://ncbi.nlm.nih.gov/pubmed/29891690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1806351115
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